Welcome to the CRYP-SKIP server!

Splice-site mutations usually induce exon skipping or cryptic splice-site activation. CRYP-SKIP employs multiple logistic regression to predict the two aberrant transcripts from the primary sequence. The server takes up nucleotide sequence of the mutated exon together with flanking intronic sequences and provides the overall probability of cryptic splice-site activation (1) as opposed to exon skipping (0). It also shows the values of the most important predictor variables for each sequence.

Insert the sequence of your exon (IN UPPER CASE) and approximately 100 nucleotides of flanking intronic sequence (in lower case) in the FASTA format in the window below. The total sequence must not be longer than 4,000 base pairs (bp). Multiple FASTA sequences with a total length of <= 4,000 bp are allowed. Click on the 'Sample sequences' button to see an example.